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使用P6.2装饰的双功能PLGA纳米颗粒进行向性输送利法西明,用于对抗金黄色葡萄球菌感染

Pelin Pelit Arayici¹, Irem Coksu², Tulin Ozbek³

¹Yildiz Technical University, Faculty of Chemical and Metallurgical, Department of Bioengineering, 34210 Esenler, Istanbul, Turkey; Health Biotechnology Joint Research and Application Center of Excellence, 34220 Esenler, Istanbul, Turkey.

Biomaterials advances

|April 28, 2024

概括

新的向纳米颗粒装载着rifaximin (RFX) 显示增强抗菌活性对黄金葡萄球菌 (S. aureus) 和甲素耐药黄金葡萄球菌 (MRSA). 这种新的方法改善了药物输送,并打击了抗生素耐药性.

科学领域:

纳米技术纳米技术
药理学药理学是一个学科.
微生物学微生物学

背景情况:

抗生素耐药性对公众健康构成重大威胁,需要新的治疗策略.
有针对性的药物输送系统通过提高疗效和减少副作用,为传统抗生素提供了有希望的替代方案.

研究的目的:

开发和评估与P6.2结合的,含有利法西明的多分子 (乳酸与甘油酸) 纳米颗粒 (TR-NP),用于针对S. aureus的向传递.
评估这些向纳米颗粒的增强抗菌活性和特异性.

主要方法:

里法西明 (RFX) 被封装成多样乳酸-协同甘油酸纳米颗粒 (PLGA NPs).
PLGA NPs被合成P6.2为有针对性的交付而装饰.
对抗黄金菌和MRSA菌株的抗菌活性进行了评估,包括最低杀菌度 (MBC) 的确定.
在体外积累研究中使用S. aureus和E. coli进行了实验.

主要成果:

在PLGANP中封装RFX提高了溶解度和受控释放,增强了抗菌活性.
通过P6.2的修改,可以将NP向S. aureus细胞的向输送.
与免费的RFX相比,向纳米粒子 (TR-NP) 显示出显著增加的抗菌活性 (32倍对S. aureus,16倍对MRSA).
TR-NP显示低MBC值为0.0078μg/mL,并表现出极好的生物相容性.

结论:

带有 P6.2 结合的 RFX 载荷的 PLGA NPs 是一种有效的,有针对性的治疗方法来对抗黄金色杆菌感染.
这种有针对性的输送系统有效地克服了传统抗生素的局限性,并且在解决抗生素耐药性方面显示出前景.

关键词:

抗微生物是一种抗微生物.药物输送是药物输送的过程.纳米颗粒是如何形成的聚乳-同-甘油酸 (Poly ((乳糖-同-甘油酸)) 是一种多种类型的酸.里法克斯小小的时间.黄金色的S. 黄金色的

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