通过吸入室内甲暴露的健康风险评估:系统性审查和元分析
Amir Hossein Khoshakhlagh1, Mahdiyeh Mohammadzadeh2, Safiye Ghobakhloo3
1Department of Occupational Health Engineering, School of Health, Kashan University of Medical Sciences, Kashan, Iran.
Journal of hazardous materials
|April 28, 2024
概括
室内吸入甲会带来严重的致癌风险,特别是在学校和高收入国家. 非致癌风险是可以接受的,但降低室内甲水平至关重要.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
背景情况:
- 室内环境是甲暴露的重要来源.
- 吸入FA与致癌性 (CR) 和非致癌性 (HQ) 的健康风险有关.
- 了解各种室内环境中的这些风险对于公共健康至关重要.
研究的目的:
- 系统地审查和对各种室内环境中FA吸入暴露的研究进行元分析.
- 量化与室内FA相关的致癌和非致癌风险.
- 为了确定室内环境中FA度和相关风险最高的室内环境.
主要方法:
- 在主要数据库 (Scopus,PubMed,Web of Science,Medline,Embase) 进行系统的文献搜索,直到2023年11月21日.
- 包括符合人口,暴露,比较和结果 (PECO) 标准的研究.
- 在5种类型的室内场地进行元分析,以确定FA度,CR和HQ值的平均效应大小 (ES).
主要成果:
- 分析了45篇文章,涵盖住房环境,教育中心,幼儿园,车和其他室内空间.
- FA度的差异很大 (0.01至1620μg/m3),其中水管咖啡馆的度最高.
- 超过90%的研究报告不确定可采取行动的致癌风险;非致癌风险通常是可以接受的.
- 在高收入国家观察到的致癌风险最高.
结论:
- 室内甲吸入具有相当大的致癌风险,特别是在教育环境和高收入国家.
- 需要有效的策略来降低室内FA度,因为人们在室内度过90%的时间.
- 定期监测室内空气质量,特别是在学校和幼儿园,对于减轻健康风险至关重要.
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