如何管理糟糕的动员者
1Department of Transfusion Medicine and Cell Therapy, Medical University Vienna, Waehringer Guertel 18-29, A-1090 Vienna, Austria.
概括
自主造血原生细胞移植 (ASCT) 需要足够的干细胞采集. 普莱里克萨福尔可以增强血液造血原生细胞 (HPC) 收集在动员不良的患者,改善ASCT成功率.
科学领域:
- 血液学 血液学 血液学
- 移植医学 移植医学
- 细胞疗法细胞疗法
背景情况:
- 自主造血原生细胞移植 (ASCT) 是各种疾病的基石疗法.
- 成功的ASCT取决于通过外周血液调动充分收集CD34+造血原生细胞 (HPC).
- 使用花细胞殖民地刺激因子 (G-CSF) 的标准动员方案并不总是有效的,导致大量患者动员失败.
研究的目的:
- 讨论与CD34+ HPC动员不良相关的风险因素.
- 总结目前优化HPC调动和收集的策略.
- 要突出plerixafor在增强ASCT干细胞采集中的作用.
主要方法:
- 关于血造原生细胞动员现有文献的综述.
- 分析导致动员失败的风险因素.
- 评估治疗策略,包括使用plerixafor,以改善HPC收集.
主要成果:
- 动员失败是由标准G-CSF或化疗动员方案后的特定低CD34+细胞计数来定义的.
- 一种CXCR4抑制剂Plerixafor是一种有效的选择,可以在动员不良的患者中增强HPC采集.
- 确定患者特定的动员不良风险因素对于实施优化策略至关重要.
结论:
- 优化CD34+ HPC调动对于成功的ASCT至关重要.
- 涉及风险因素评估和向干预措施的策略,如plerixafor可以改善干细胞采集.
- 对动员失败的预防和救援策略进行进一步的研究是有必要的.
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