肠道微生物群温和多模式大脑结构-功能整合和行为认知在生长激素缺乏的儿童中
Keren Wang1, Yuchuan Fu1, Lan Li1
1Department of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Neuroendocrinology
|April 28, 2024
概括
多式脑成像和肠道微生物组分析显示,生长激素缺乏 (GHD) 和异常矮身 (ISS) 的儿童的肠道-大脑轴有明显的模式,影响认知功能.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 儿科 儿科 儿科
背景情况:
- 增长激素缺乏 (GHD) 研究往往缺乏多式神经成像,限制了对其复杂性的理解.
- 在GHD和特异性矮身 (ISS) 中,肠-大脑轴 (GBA) 仍然不清楚,特别是关于大脑发育和微生物群.
- 调查GBA异常对于理解GHD和ISS病理生理学至关重要.
研究的目的:
- 探索GHD和ISS儿童的肠-大脑轴 (GBA) 现象.
- 整合多式神经成像与肠道微生物群数据以发现GBA差异.
- 确定微生物群变化如何影响GHD和ISS中的神经成像-认知关系.
主要方法:
- 融合独立组件分析整合了23名GHD和25名国际空间站儿童的多模式MRI数据 (结构,扩散,静止状态fMRI).
- 分析了区域同质性 (ReHo),低频波动幅度 (ALFF) 和分数异质性 (FA).
- 评估了肠道微生物组多样性 (16S测序) 和代谢物 (1H-NMR),并检查了认知关联.
主要成果:
- ReHo,ALFF和FA的六个独立组件在GHD和ISS之间存在显著差异.
- 三个功能组件与GHD和ISS中的处理速度指数相关联.
- GHD显示微生物代谢物 (乙酸,尼古丁酸,氨酸) 发生变化;微生物群多样性影响了神经成像-认知联系.
结论:
- GHD与明显的脑结构和功能连接模式有关,以及改变的肠道微生物群代谢.
- 微生物组的组成和多样性显著调节神经成像发现和认知表现之间的关系.
- 这些发现为GHD和ISS的GBA病理生理学提供了新的见解,为潜在的干预提供了信息.
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