传统的心血管风险因素和冠状动脉微血管功能障碍在女性和男性:一个单中心研究
Lior Zornitzki1,2, Aviel Shetrit1, Ophir Freund2
1Department of Cardiology, Tel Aviv Sourasky Medical Center, Affiliated with Tel Aviv University School of Medicine, Tel Aviv, Israel.
Cardiology
|April 28, 2024
概括
冠状动脉微血管功能障碍 (CMD) 是常见的,但传统的风险因素与之无关. 在女性中,年龄较大和先前的缺血性心脏病与CMD有关,突出了性别特异性差异.
科学领域:
- 心脏病学 心脏病学
- 血管医学 血管医学
- 心血管研究研究心血管研究
背景情况:
- 冠状动脉微血管功能障碍 (CMD) 影响了许多患有或没有阻塞性冠状动脉疾病 (CAD) 的患者.
- 对于CMD发展的风险因素仍然不清楚,特别是关于CMD患者中阻塞性CAD传统心血管风险因素的基于性别的差异.
研究的目的:
- 研究冠状动脉微血管功能障碍 (CMD),传统心血管风险因素和非阻塞性冠状动脉疾病 (CAD) 患者的性别之间的关联.
主要方法:
- 一个单一中心的前性注册表注册了245名非阻塞性CAD患者,他们正在进行冠状动脉微血管功能的侵入性评估.
- 用单变量和多变量回归模型来分析CMD,风险因素和性别之间的关联.
主要成果:
- 在女性 (59.0%) 和男性 (57.0%) 中,CMD的患病率相似.
- 在整体人口中,传统冠状动脉样硬化风险因素和CMD之间没有发现任何关联.
- 仅在女性中,年龄较大和先前的缺血性心脏病与降低的冠状动脉流量储备和电阻储备比率有关.
结论:
- 冠状动脉样硬化的传统风险因素在研究的一般人群中与冠状动脉样硬化无关.
- 老年和先前的缺血性心脏病独立地与CMD有关,特别是在女性中.
- 需要在更大的队列中进行进一步的研究,以充分阐明CMD的风险因素.
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