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Updated: Jan 7, 2026

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale
08:49

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale

Published on: May 28, 2021

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在KoCVAM的带领下,使用重建的人类表皮模型 (KeraSkinTM) 开发了光毒性替代测试方法

Nam-Hee Kang1, So-Hee Kim1, Joohwan Kim1

  • 1Korean Center for the Validation of Alternative Methods (KoCVAM), Nonclinical Resource Research Division, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongju-si, 28159, Republic of Korea.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
|April 28, 2024
PubMed
概括

在KeraSkinTM光毒性测试准确地预测化学光毒性. 这种新的体外法,根据经合组织的指导方针进行验证,显示出100%的准确性,灵敏性和对光毒性潜力的特异性.

关键词:
另类测试试验 替代测试试验在 KoCVAM 找 KoCVAM经合组织经济合作与发展组织TG498摄影毒性 摄影毒性重建的人类表皮 (RhE)

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Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform06:30

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An In Vitro Skin Irritation Test SIT using the EpiDerm Reconstructed Human Epidermal RHE Model21:16

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相关概念视频

Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
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