口腔状细胞癌细胞的增长抑制由乳杆菌酸性菌的细胞
Adel Al-Asfour1, Radhika G Bhardwaj2, Maribasappa Karched3
1Department of Surgical Sciences, College of Dentistry, Kuwait University, Kuwait City, Kuwait.
International dental journal
|April 28, 2024
概括
益生菌Lactobacillus acidophilus通过诱导亡,对口腔状细胞癌 (OSCC) 产生抗癌作用. 突变性链球菌不会阻碍这种抗增殖潜力,这表明L. acidophilus在OSCC治疗中的治疗应用.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 口腔状细胞癌 (OSCC) 是一种侵袭性癌症.
- 益生菌乳酸菌,包括Lactobacillus acidophilus,表现出抗癌性质.
- L. acidophilus,Streptococcus mutans和OSCC之间的相互作用尚未得到充分理解.
研究的目的:
- 为了研究L. acidophilus对OSCC细胞的抗增殖作用.
- 为了确定S. mutans对OSCC细胞的影响.
- 评估S. mutans是否影响L. acidophilus对OSCC的抗增殖活性.
主要方法:
- 人口状细胞癌细胞 (HNO97) 用L. acidophilus和S. mutans单独和组合治疗.
- 使用MTT试验评估了细胞活力.
- 分析了细菌粘附,诱导亡 (Nexin染色) 和 TRAIL基因/蛋白质表达 (RT-PCR,ELISA).
主要成果:
- L. acidophilus和S. mutans对HNO97细胞表现出显著的抗增殖活性.
- 这两种细菌都附着在OSCC细胞上,并诱导了亡.
- 与瘤亡因子 (TNF) 相关的诱导亡联体 (TRAIL) 表达显著增加,特别是在联合细菌治疗时.
结论:
- L. acidophilus对OSCC具有抗增殖作用,部分是通过 TRAIL介导的亡.
- S. mutans的存在不会降低L. acidophilus的抗增殖潜力.
- 益生菌L. acidophilus需要进一步研究OSCC的治疗用途.
关键词:
细胞灭亡 (apoptosis) 是一种死亡的过程.乳酸菌酸性菌类的乳酸菌.口腔癌是一种口腔癌.口腔状细胞癌的癌症.益生菌 益生菌 益生菌突变型链球菌 (Streptococcus mutans) 是一种突变型链球菌与TNF相关的诱导亡的配体.更多相关视频
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