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在玻璃中和在中,在纹理的心室管上对Thrombi聚合的表征
Wenxuan He1, Abhishek Karmakar2, Junhyuk Kang1
1Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, 14853, USA.
Annals of biomedical engineering
|April 28, 2024
概括
该HeartMate 3心室辅助器件 (VAD) 输入管输入管.
科学领域:
- 生物医学工程 生物医学工程
- 心血管研究研究心血管研究
- 血液动力学 血液动力学
背景情况:
- 高中风率与HeartMate 3心室辅助装置 (VAD) 有关.
- 这种并发症发生在没有血栓的证据的情况下,这表明了另一个原因.
- 来自输入道的栓塞被假定会导致中风.
研究的目的:
- 为了研究腹腔管的表面特征和剪切速率在血栓形成中的作用.
- 为了模拟HeartMate 3在体外和通过数值模拟中体验到的条件.
- 了解导致栓塞形成和潜在中风风险的机制.
主要方法:
- 在1000-7500s-1的剪切速率下,在微流体通道中输入人体全血.
- 使用带有周期牙的通道来模仿VAD管的粗烧结表面.
- 使用实体跟踪实时可视化和分析光标记的血小板沉积.
- 使用多成分模型进行血流和血栓形成的数值模拟.
主要成果:
- 持续的血小板沉积发生在所有测试的剪切率.
- 在较低的剪切率下观察到最大的血小板沉积.
- 与通道的"牙"相对的血小板沉积位置因剪切率而异,由CFD模拟证实.
- 实体跟踪揭示了栓塞事件的空间变化.
结论:
- 腹腔管的烧结表面可能会促进不稳定的血栓的形成.
- 这些血栓可能会增加栓塞的可能性,特别是在超生理剪切率.
- 这一发现提供了与VAD相关的中风风险的洞察力,并表明了设备修改的潜在领域.
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