在中年和老年中国普通人口中,多重金属暴露和全身免疫炎症之间的关联
Linhai Zhao1, Yanfei Wei2, Qiumei Liu1
1Department of Occupational and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
铜和等重金属与增加的炎症标志物有关,而铁具有保护作用. 这项研究探讨了中国成年人血重金属和系统性免疫炎症之间的关联.
科学领域:
- 环境健康 环境健康
- 免疫学 免疫学 免疫学
- 毒理学 毒理学 毒理学
背景情况:
- 暴露在重金属中,单独或联合,可以引发全身炎症.
- 了解多种重金属与免疫反应之间的相互作用对于公共卫生至关重要.
研究的目的:
- 调查血重金属水平和全身免疫炎症标志物之间的关联.
- 分析多种重金属对免疫标记物的综合作用.
主要方法:
- 在中国广西,对3355名参与者的横截面研究.
- 使用感应合等离子体质谱测量等离子体重金属.
- 来自白细胞计数的免疫炎症标志物;使用通用线性回归和加权定量总和 (WQS) 回归分析.
主要成果:
- 血铜 (Cu) 和 (Mn) 与系统性免疫炎症指数 (SII),中性粒细胞与淋巴细胞比率 (NLR) 和血小板与淋巴细胞比率 (PLR) 呈正相关性.
- 血铁 (Fe) 与SII,NLR和PLR负相关.
- 在WQS回归中,Cu和Mn被确定为积极关联的关键贡献者,而Fe则显示出对炎症标志物的保护作用.
结论:
- 血Cu和Mn与系统性免疫炎症标志物增加有关.
- 血Fe与这些炎症标志物具有反向关系.
- 这些发现突出了各种重金属对全身炎症的影响.
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