鼻氧化的预测价值用于诊断异敏性慢性鼻炎:系统性审查和元分析
Do Hyun Kim1, Hyesoo Shin1, Gulnaz Stybayeva2
1Department of Otolaryngology-Head and Neck Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
American journal of rhinology & allergy
|April 28, 2024
概括
鼻氧化物 (NO) 显著高于埃索因性慢性鼻炎 (ECRS) 患者. 这一发现表明鼻腔NO可以成为诊断ECRS的宝贵的非侵入性工具.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 肺部病理学 肺部病理学
- 生物标志物 生物标志物
背景情况:
- 异性慢性鼻炎 (ECRS) 是一种复杂的炎症状况.
- 准确的诊断和内型鉴定对于ECRS的有效管理至关重要.
- 需要非侵入性生物标志物来帮助ECRS诊断.
研究的目的:
- 为了比较ECRS和没有ECRS的患者的鼻氧化 (NO) 水平.
- 评估用于诊断ECRS的鼻腔NO的预测值.
主要方法:
- 一个系统的审查和对研究的元分析,比较ECRS和非ECRS队列中的鼻NO水平.
- 对ECRS的鼻腔NO的区分能力的量化.
- 使用纽卡斯尔-太华尺度进行偏差风险评估.
主要成果:
- 纳入了5项与470名参与者的研究.
- 在ECRS患者中,鼻腔NO水平显著提高 (平均差异为130.03ppb).
- 鼻腔NO显示ECRS的诊断几率比为9.29,AUC为0.82.
结论:
- 在患有ECRS的个体中,鼻NO水平升高.
- 鼻腔NO显示出作为ECRS的非侵入性诊断标记物的潜力.
- 鼻腔NO可以作为ECRS的内型化工具.
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