相关实验视频
Updated: Jun 27, 2025

10:31
Antigenic Liposomes for Generation of Disease-specific Antibodies
Published on: October 25, 2018
12.4K
促进对参加血液学诊所的儿童进行青素过敏脱标
Patricia Barker1, Delia Charest Carias1, Timothy Jacobs1
1Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Pediatric blood & cancer
|April 29, 2024
概括
在小儿血液病患者中,对青素过敏的取消标签 (ADL) 是可行的. 一个由药剂师领导的过程成功地通过图表审查,采访和测试来删除不准确的青素过敏标签,改善了获得关键抗生素的机会.
科学领域:
- 儿科过敏和免疫学
- 药理学 药理学是指药理学的学科.
- 血液学 血液学 血液学
背景情况:
- 许多被标记为青素过敏的儿童缺乏经过验证的过敏症,导致不良结果.
- 不准确的青素过敏标签阻碍了患有频繁感染的小儿血液病患者的治疗.
- 过敏脱标 (ADL) 可以改善这些患者获得β-乳糖抗生素的机会.
研究的目的:
- 实施和评估一个多学科的,药剂师驱动的过程,以消除青素过敏的标签.
- 为了使非过敏症提供者能够在儿科血液学环境中评估和删除不准确的青素过敏标签.
主要方法:
- 在皮肤测试和口腔挑战程序中接受过培训的医疗保健专业人员.
- 通过电子健康记录识别了带有青素过敏标签的患者.
- 进行了图表审查和患者/家庭采访,以评估过敏的真实性.
- 当过敏仍然不确定时,提供皮肤和/或口服挑战测试.
主要成果:
- 在最初标记的59名患者中,有19%的患者在图表审查后被取消标签,25%的患者在采访后被取消标签.
- 44%的患者接受过敏测试 (皮肤或口腔挑战),88%的测试呈阴性.
- 在很大一部分患者中,ADL是成功的,测试耐受性很好.
结论:
- 对青素过敏的取消标签在大多数儿科血液病患者中是可以实现的.
- 实施的多学科过程促进了安全有效的过敏脱标.
- 成功的ADL改善了血液学疾病患者的抗生素选择.
相关概念视频
Allergic Reactions
27.3K
Overview
27.3K
Hypersensitivities
620
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
620
Allergic Drug Reactions
838
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
838

