在1型糖尿病中,与代谢功能障碍相关的脂肪性肝病的患病率和预测特征
Coco M Fuhri Snethlage1, Abraham S Meijnikman1, Anne Linde Mak1
1Department of Vascular Medicine, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, AZ 1105, The Netherlands.
European journal of endocrinology
|April 29, 2024
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 影响了近10%的1型糖尿病患者. MASLD严重程度的关键预测因素包括糖尿病持续时间较长,年龄较大,BMI较高和高血压.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
- 糖尿病学 糖尿病学
背景情况:
- 在1型糖尿病 (T1D) 中,代谢功能障碍相关的脂肪性肝病 (MASLD) 的患病率和严重程度尚不清楚.
- 了解这些因素对于管理T1D并发症至关重要.
研究的目的:
- 为了确定T1D队列中MASLD的患病率和严重程度.
- 确定T1D患者中MASLD严重程度的临床预测因素.
主要方法:
- 振动控制的短暂弹性图 (VCTE) 用于评估453名T1D患者的肝硬化症 (CAP分数) 和纤维化 (LMS).
- 一个机器学习的Extra-Trees分类模型分析了临床特征的预测能力.
主要成果:
- 肝硬化和纤维化的患病率分别为9.5%和3.5%.
- 较高的肝硬度 (纤维化) 与较长的T1D持续时间,年龄较大,较高的BMI和较高的CAP分数相关.
- 纤维化预测因素包括T1D持续时间,年龄和缩血压 (AUC 0.73).
结论:
- 患有T1D,高血压,年龄较大,BMI较高,疾病持续时间较长的人患MASLD的风险增加.
- 这些临床特征可以帮助识别高风险T1D患者,以便更密切地监测和干预.
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