长非编码RNAHOTAIR上调与乳腺癌的不良结果有关:系统性审查和元分析
Suwardjo Suwardjo1, Kavi Gilang Permana1, Teguh Aryandono1
1Division of Surgical Oncology Department of Surgery, Dr Sardjito Hospital / Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Indonesia.
Asian Pacific journal of cancer prevention : APJCP
|April 29, 2024
概括
长非编码RNAHOTAIR (HOX转录反意义RNA) 的高表达与乳腺癌患者的生存结果较差有关. 这一发现表明HOTAIR可以作为乳腺癌预后的有价值的预后标记.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 乳腺癌是全球女性癌症死亡的主要原因,在发展中国家的影响明显.
- 改善预后和复发标记对于完善乳腺癌临床管理至关重要.
- 长非编码RNAHOTAIR (HOX转录反意义RNA) 已成为与不良结果相关的潜在预后指标.
研究的目的:
- 系统地评估长非编码RNAHOTAIR表达和乳腺癌患者的存活率之间的关联.
- 通过元分析综合现有研究的证据,以确定HOTAIR的预后价值.
主要方法:
- 在主要的科学数据库 (PubMed,Scopus,Google Scholar等) 进行了全面的文献搜索. ) 的情况.
- 关键词包括"长非编码RNA"",lncRNA"",HOTAIR"",乳腺癌"",预后"和"生存".
- 对7项涉及533名患者的研究进行了元分析,以评估HOTAIR表达和生存结果之间的关系,使用STATA v.17.
主要成果:
- 高HOTAIR表达显着与较差的整体存活率 (汇总HR: 1.69) 和无病存活率 (汇总HR: 2.40) 相关.
- 升高的HOTAIR水平与远程转移性无存活率降低相关 (HR: 1.75) 并与导管癌类型相关 (合并OR: 3.27).
- 虽然与积极的淋巴结透有关 (合并OR:2.38),但这没有达到统计学意义 (p=0.26).
结论:
- 在乳腺癌中,lncRNA HOTAIR的上调是较差无疾病生存率和远程无转移性生存率的重要指标.
- 霍泰尔具有作为预后生物标志物的潜力,用于识别患有复发和转移风险更高的乳腺癌患者.
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