甲状腺反基于量子的指数和正常甲状腺功能的人群中的心血管疾病之间的关系:来自2007-2012年国家健康和营养检查调查的证据
Hui Li1,2, Xue Liu3, Xinhui Wang3
1Jinan University, Guangdong, Guangzhou, China.
Clinical cardiology
|April 29, 2024
概括
甲状腺功能中心敏感度指数 (TFQI) 与甲状腺功能正常的个体的心血管疾病 (CVD) 风险有关. 更高的TFQI表明心血管疾病风险增加,这表明能量代谢在心血管健康中的作用.
科学领域:
- 内分泌学 在内分泌学.
- 心血管医学 心血管医学
- 代谢健康 代谢健康
背景情况:
- 以前的研究将甲状腺功能中心敏感度指数 (TFQI) 与肥胖,糖尿病和代谢综合征联系起来.
- TFQI反映了甲状腺激素的中心敏感性.
- TFQI与心血管疾病 (CVD) 之间的关联在平甲状腺患者中仍然未确立.
研究的目的:
- 研究甲状腺功能正常的个体中TFQI和心血管疾病患病率之间的关系.
- 确定TFQI是否是心血管疾病的独立风险因素.
主要方法:
- 在NHANES (2007-2012) 中,对6297名甲状腺功能良好的个人进行了回顾性队列研究.
- 使用FT4和TSH水平计算的TFQI.
- 使用多变量线性回归和分层分析来评估TFQI与心血管疾病的关联,控制共变量.
主要成果:
- 与没有心血管疾病的人相比,患有心血管疾病的人的TFQI水平显著更高.
- 在调整后,TFQI显示了与心血管疾病风险的积极关联 (OR=1.706,p=0.005).
- 升高的TFQI与女性和BMI>28 kg/m2的个体心血管疾病风险增加有关.
结论:
- TFQI水平与心血管疾病在无甲状腺患者的患病率密切相关.
- 这表明能量代谢在心血管疾病的发病过程中可能发挥作用.
- TFQI可以作为评估心血管风险的新生物标志物.
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