糖尿病和冠状动脉疾病作为痴呆症的危险因素
Kevin K W Olesen1,2, Pernille G Thrane1, Christine Gyldenkerne1,3
1Department of Cardiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark.
European journal of preventive cardiology
|April 29, 2024
概括
糖尿病和冠状动脉疾病 (CAD) 显著增加痴呆症风险,特别是血管痴呆症. 在糖尿病患者中治疗动脉样硬化心血管疾病 (CVD) 对认知健康至关重要.
科学领域:
- 老年学是指老年学的学科.
- 神经学 神经学
- 心脏病学 心脏病学
背景情况:
- 糖尿病是一种已知的痴呆症风险因素.
- 动脉样性心血管疾病 (CVD) 影响这种风险的程度仍在争论中.
- 冠状动脉疾病 (CAD) 作为系统性动脉样硬化心血管疾病的标志物.
研究的目的:
- 调查糖尿病和CAD在痴呆症发展上的联合风险.
- 为了确定CAD是否会加剧与糖尿病相关的痴呆风险.
主要方法:
- 对103,859名65岁以上的患者进行了回顾性队列研究,这些患者接受了冠状动脉血管学.
- 患者分为四组:仅糖尿病,仅CAD,糖尿病与CAD,没有.
- 痴呆症结局 (所有原因,阿尔茨海默氏症,血管) 分析使用调整后的危险比率 (aHR),随访时间中位数为6.3年.
主要成果:
- 患有糖尿病和CAD的患者表现出所有原因痴呆症 (aHR 1.37) 和血管痴呆症 (aHR 2.03) 的最高风险.
- 仅糖尿病就显示了所有原因痴呆风险的适度增加 (aHR 1.14).
- 单独的CAD也显示出所有原因痴呆风险的适度增加 (aHR 1.11).
结论:
- 糖尿病和CAD的共存大大提高了痴呆症的风险,特别是血管痴呆症.
- 这表明动脉样硬化心血管疾病部分调解了与糖尿病相关的痴呆风险.
- 强调对糖尿病患者进行心血管疾病预防策略的关键需求,以保持认知功能.
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