来自八个化学品类的抗菌剂,防腐剂和危害评估
Lauren Lynn1, Rachel C Scholes1,2, Jong H Kim3
1Bioproducts Research Unit, Western Regional Research Center, USDA-ARS, 800 Buchanan St., Albany, California 94710, United States.
ACS omega
|April 29, 2024
概括
与传统选择相比,确定了更安全的防腐剂,如烯酸和烯糖醇,提供有效的微生物保护,降低了人类和环境风险.
科学领域:
- 消费者产品安全 消费者产品安全
- 抗微生物疗效 抗微生物疗效
- 毒理学 毒理学 毒理学
背景情况:
- 防护剂防止消费品中的微生物污染,确保安全性和稳定性.
- 常见的防腐剂,如异醇和甲释放剂,对人类和环境构成危险.
- 开发更安全的替代品是具有挑战性的,因为有效性和安全性的权衡.
研究的目的:
- 找出更安全的防腐剂替代品,减少对人类和环境的危害.
- 评估一系列广泛的物质对抗微生物药物的有效性和安全性.
- 为了能够明智地选择防腐剂,平衡性能和风险.
主要方法:
- 在8个功能类别中选了130种物质,以检测它们对*Aspergillus brasiliensis*和*Pseudomonas aeruginosa*的抗菌活性.
- 对人类和环境的危害进行评估的高性能化合物.
- 在使用USP-51指南的模型家庭护理配方中测试了有前途的候选人.
主要成果:
- 确定了酸和酸甘醇作为有效的防腐剂.
- 这些化合物与异硫和甲释放剂相比,显示出更好的毒性概况.
- 突出了抗微生物活性和化学品类中的危险概况之间的固有权衡.
结论:
- 酸和酸糖是消费品中更安全的防腐剂选择.
- 这项研究为开发能够平衡有效性与降低毒性的防腐剂提供了框架.
- 开发更安全的防腐剂需要仔细考虑性能和健康/环境影响.
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