具有基于电子束辐射终端杀菌方法的凝形成和稳定性质的临床适用碳素甲基基托
Huili Yuan1,2,3, Wenjing Liu1,2,3, Yu Fu1,2,3
1College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou 310014, PR China.
ACS omega
|April 29, 2024
概括
软化碳甲基酸盐 (CMC) 水凝可以使用电子束 (EB) 辐射有效消毒. 这种方法保存了CMC.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 消毒技术 消毒技术
背景情况:
- 基于碳氧甲基基托 (CMC) 的水凝显示出临床使用的前景.
- 杀菌是CMC水凝进入市场的关键步骤.
- 传统的灭菌方法,如乙烯氧化物或热能,可能会损害多糖.
研究的目的:
- 为CMC水凝开发一个合适的灭菌方法.
- 为了应对辐射过程中多糖分解的挑战.
- 为了验证冷化CMC的电子束 (EB) 辐射.
主要方法:
- 福里埃变换红外光谱 (FTIR) 用于结构分析.
- 热重力测量分析 (TG) 测量热稳定性.
- 凝透色谱 (GPC) 用于分子量测定.
- 微生物负荷测试用于杀菌的有效性.
主要成果:
- 对冷化CMC的EB辐射并没有显著改变其结构或分子量.
- 淋化CMC满足了杀菌要求.
- 辐射后保留了CMC的凝特性和稳定性.
结论:
- 解热化CMC适用于电子束 (EB) 灭菌.
- 经过EB辐射,可以保持CMC水凝的临床适用性.
- 这种方法为多糖水凝提供了一个新的灭菌策略.
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