精神分裂症和多克索普拉斯莫斯症:与触动性症状的关联
Dmitry V Romanov1,2, Aleksey Iu Brazhnikov1, Denis S Andreyuk3,4
1I.M. Sechenov First Moscow State Medical University (Sechenov University).
Consortium psychiatricum
|April 29, 2024
概括
在精神分裂症患者中,毒素菌感染与触动性症状有关,而不是整体症状严重程度. 这项研究在阳性人群中发现了较高的catatonia和mutism率,这表明了特定的临床关联.
科学领域:
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
- 精神病学是一个精神病学.
背景情况:
- 精神分裂症与较高的毒素菌的患病率有关.
- 这种关联的临床意义尚不清楚.
研究的目的:
- 为了确定与Toxoplasma gondii (T. gondii) 血清阳性相关的精神分裂症中的特定临床现象.
主要方法:
- 使用ELISA对105名精神分裂症患者的血清样本进行了T. gondiiIgG抗体的回顾性分析.
- 临床评估包括ICD-10和E.布莱勒标准,以及正负综合征量表 (PANSS).
- 统计分析采用了曼-惠特尼 (U) 和奇平方 (X2) 试验.
主要成果:
- 16.2%的精神分裂症患者对T. gondii呈阳性.
- 血清阳性和血清阴性组之间的总体PANSS分数没有显著差异.
- 血清阳性患者的态度/姿势 (G5,G6) 得分显著更高,沉默和触动症状的频率更高.
- 血清阳性患者表现出不那么明显的抑郁症.
结论:
- 在精神分裂症患者中,阳性Toxoplasma gondii状态与触动性症状有关,包括变异性.
- 这是第一个报告毒素菌和精神分裂症中catatonia之间的关联的研究.
- 需要对更大的队列进行进一步的研究来验证这些发现.
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