探索基碳化合物受体在瘤微环境中的表达和分布,重点是免疫细胞,在各种固体癌症类型中
Dong Kwon Kim1,2, Chai Young Lee2, Yu Jin Han2
1Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea.
Frontiers in immunology
|April 29, 2024
概括
基碳化合物受体 (AhR) 存在于瘤微环境中的癌细胞和免疫细胞中. 它的表达模式因癌症类型而异,为针对AhR的癌症疗法提供了潜在的生物标志物.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 基碳化合物受体 (AhR) 是一种联体激活的转录因子,参与瘤进展和免疫监测.
- 关于瘤微环境 (TME) 内的AhR表达分布的数据有限.
- 了解AhR分布是开发针对AhR的抗癌剂和生物标志物的关键.
研究的目的:
- 研究TME内的癌细胞和免疫细胞中AhR的表达和分布.
- 分析核和细胞质AhR表达之间的相关性.
- 在不同癌症类型中识别潜在的AhR表达模式.
主要方法:
- 使用多重复合免疫组织化学 (mIHC) 和图像细胞计.
- 对513例患者样本进行了分析,其中292例患有固体瘤.
- 核和细胞质AhR定位被特别检查.
主要成果:
- 主要在癌细胞中观察到AhR的表达,其次是 stromal T细胞和巨细胞.
- 发现了核和细胞质AhR表达之间的正相关性.
- 在癌症类型中确定了三个不同的AhR表达集群,在非小细胞肺癌 (NSCLC) 中,调节性T细胞 (Tregs) 的高水平.
结论:
- 在TME内的各种细胞类型中存在AhR表达.
- AhR局部化 (核/细胞质) 不会影响其作为生物标记物的潜力.
- 癌症特异性的AhR表达模式,特别是在NSCLCTregs中,需要进一步研究治疗策略.
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