住院两年后的COVID-19后呼吸系统后果:一个双向研究
Carlos Roberto Ribeiro Carvalho1, Celina de Almeida Lamas1, Luis Augusto Visani de Luna1
1Division of Pulmonary Medicine, Heart Institute, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Lancet regional health. Americas
|April 29, 2024
概括
肺部异常在COVID-19幸存者中持续并恶化,在出院18-24个月后,出现新的纤维状病变. 重症监护室 (ICU) 停留和更长的住院预测这些长期的COVID肺部后果.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 放射学 放射学是一门学科.
背景情况:
- COVID-19肺部后果可能会显著影响患者的康复和长期健康.
- 了解住院后肺部异常的进展对于患者管理至关重要.
研究的目的:
- 为了调查COVID-19幸存者肺部异常的演变在医院出院18-24个月后.
- 在COVID-19后的患者中确定纤维状肺病变的发展预测因素.
主要方法:
- 一组住院COVID-19患者的肺部参与被跟踪18-24个月后出院.
- 胸部计算机断层扫描 (CT) 扫描和功能评估在出院后6-12个月和18-24个月之间进行了比较.
- 进行了回顾性和前性数据分析,以确定肺部连续病变的预测因素.
主要成果:
- 在237名参与者中,58%的受试者有地面玻璃的不透明度/网膜,33%的受试者在18-24个月时有纤维状病变.
- 与6-12个月的随访相比,观察到建筑扭曲和引支气管支气管的增加.
- 观察到持续的功能障碍,包括限制性模式和减少的扩散能力.
- 住院时间长,侵入性机械通风和患者年龄预测了纤维状肺病变.
结论:
- 后COVID-19肺部后果可能会持续和进展,形成新的纤维状病变.
- 需要入住重症监护室 (ICU) 的患者尤其面临发展渐进性肺损伤的风险.
- 这些发现凸显了对COVID-19幸存者的长期监测的必要性.
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