代谢综合征和经过皮肤利切除术的患者的尿路微生物群
Ryan A Dornbier1, Chirag P Doshi1, Shalin C Desai1
1Loyola University Medical Center, Department of Urology, Maywood, IL, USA.
Asian journal of urology
|April 29, 2024
概括
细菌在代谢综合征 (MetS) 患者的结石中更为普遍. 这表明,无论石头类型如何,微生物都在MetS患者的石头形成中发挥作用.
科学领域:
- 微生物学 微生物学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 代谢疾病 代谢疾病
背景情况:
- 代谢综合征 (MetS) 与尿路结石疾病有关,但潜在的机制尚不清楚.
- 尿路失生症是可能增加结石病风险的因素.
- 识别促进结石的微生物对于理解这种关联至关重要.
研究的目的:
- 为了比较患有代谢综合征 (MetS) 和没有代谢综合征 (MetS) 的患者结石中的微生物概况.
- 为了研究细菌在尿路结石病变中的作用,在MetS患者.
主要方法:
- 在MetS和对照患者的皮穿性利切除过程中收集了膀尿液和石块碎片.
- 利用扩展量化尿液培养 (EQUC) 和16S核糖体RNA基因测序进行微生物分析.
- 从两个队伍的石头样本中比较细菌的存在和丰富性.
主要成果:
- 细菌被检测的频率更高 (42.2% vs 8.3%,p=0.041) 和在石头更丰富的MetS患者比对照.
- 16S rRNA基因测序验证了EQUC发现,在75%的测序阳性石头中发现了细菌.
- 在"传染性"和"非传染性"石材组合中观察到细菌存在.
结论:
- 细菌在与代谢综合征相关的结石中更为常见和丰富.
- 这些发现支持细菌在患有MetS的患者尿路结石疾病中的作用,无论结石成分如何.
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