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瘤死亡因子-α,转化生长因子-β,下泌尿道症状的程度作为良性前列腺增生患者勃起功能障碍的预测因素

Gede W K Duarsa¹, Yeremia G Kusumah², Ronald Sugianto³

¹Department of Urology, Faculty of Medicine, Universitas Udayana, Prof. Dr. I.G.N.G Ngoerah General Hospital, Bali, Indonesia.

Asian journal of urology

|April 29, 2024

概括

瘤坏死因子-α (TNF-α) 和转化生长因子-β (TGF-β) 在良性前列腺增生 (BPH) 患者中显著预测勃起功能障碍 (ED). 下尿道症状也与ED相关,但前列腺大小没有.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
安德罗学与人类学
医学生物化学医学生物化学

背景情况:

勃起功能障碍 (ED) 是一种影响性活动的常见疾病,通常与良性前列腺增生 (BPH) 相关.
瘤亡因子-α (TNF-α) 通过诱导转化生长因子-β (TGF-β) 的诱导,涉及ED的发病因子,它促进影响阴茎功能的细胞变化.

研究的目的:

调查TNF-α,TGF-β水平,下泌尿道症状 (LUTS) 和前列腺体积与BPH患者ED存在之间的关联.
在BPH的背景下确定ED的关键预测因素.

主要方法:

通过使用来自印度尼西亚四家医院的二次数据,进行了一项分析观察后期队列研究.
分析了BPH患者的医疗和行政记录,包括对LUTS (国际前列腺症状评分),TNF-α,TGF-β水平和前列腺体积的评估.

主要成果:

在较高的国际前列腺症状评分和ED的患病率 (p=0.002) 之间发现了显著的相关性.
高水平的TNF-α (≥43.9 pg/mg) 和TGF-β (≥175.8 pg/mL) 与BPH患者的ED存在显著相关 (p<0.0001).
前列腺体积与ED没有显著的关联 (p=0.947).

结论:

TNF-α,TGF-β和下泌尿道症状的严重程度是BPH患者ED的显著预测因素.
前列腺体积不是预测ED的重要因素在这个队列中的BPH患者中.
这些发现突显了炎症和纤维化途径在与BPH相关的ED发展中的作用.

关键词:

生物标志物生物标志物勃起功能障碍是因为勃起功能障碍.前列腺扩大前列腺扩大风险因素风险因素风险因素

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