与代谢功能障碍相关的脂肪肝疾病的基于激素的药物治疗
Zara Siu Wa Chui1,2,3, Yaqian Xue1,2, Aimin Xu1,2,4
1State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong SAR, China.
Medical review (2021)
|April 29, 2024
概括
新的基于激素的药物显示出治疗代谢功能障碍相关的脂肪肝疾病 (MAFLD) 的前景. 作为THRβ激动剂的resmetirom有效地治疗了晚期MAFLD (MASH) 和纤维化,这表明组合疗法可以提供协同效益.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 代谢功能障碍相关的脂肪肝疾病 (MAFLD) 是与肥胖相关的全球流行病,没有批准的向疗法.
- 对MAFLD药物的临床试验因安全性和有效性问题而面临挑战.
研究的目的:
- 审查激素模仿药物对MAFLD的治疗潜力.
- 为了强调resmetirom在治疗MASH和肝纤维化方面的成功.
- 探索对MAFLD的组合疗法的潜力.
主要方法:
- 对模仿甲状腺激素受体β (THRβ),纤维细胞生长因子21 (FGF21) 和类似葡萄糖-1 (GLP-1) 的试验药物的审查.
- 对临床试验数据的分析,重点关注resmetirom的疗效和安全性.
- 评估基于激素治疗的补充机制.
主要成果:
- 选择性THRβ激动剂Resmetirom在MASH和肝纤维化3期试验中取得了主要结果.
- 实验性药物如THRβ激动剂,FGF21类似物和GLP-1RAs显示出有前途的疗效和安全性.
- 这些药物可以改善肝脏肥胖症,炎症,纤维化和代谢状况.
结论:
- 基于激素的药物治疗为MAFLD治疗提供了一个有希望的途径.
- 针对补充性荷尔蒙路径的联合疗法可能产生协同效益.
- 对激素相互作用的进一步研究对于开发精确的MAFLD管理策略至关重要.
相关概念视频
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
652
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
652
Overview of Lipid Metabolism
1.5K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.5K
Liver Physiology
518
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
518
Overview of Fatty Acid Metabolism
30.6K
Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
30.6K
Diabetes: Management and Pharmacotherapy
268
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
268
Cholesterol: Significance and Regulation
540
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
540


