糖尿病患者残留胆固醇水平与死亡率之间的关联
Deng Pan1,2,3, Lin Xu4, Li-Xiao Zhang1,3
1Department of Cardiovascular, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China.
World journal of diabetes
|April 29, 2024
概括
在糖尿病患者中,较高的残留胆固醇与增加的死亡风险有关. 然而,略高的残留胆固醇水平可能会对所有原因的死亡率产生保护作用.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 流行病学 流行病学
背景情况:
- 脱脂症在糖尿病患者中很常见.
- 剩余胆固醇与糖尿病死亡率之间的关系尚未完全理解.
研究的目的:
- 研究糖尿病患者残留胆固醇与全因和心血管死亡率之间的关联.
主要方法:
- 从NHANES (1999-2018) 中对4740名糖尿病患者进行前性队列研究.
- 作为暴露的残留胆固醇;所有原因和心血管死亡率作为结果.
- 考克斯回归模型和受限立方线分析了关联;进行了子组和灵敏度分析.
主要成果:
- 在83个月的中位数随访期间,发生了1370起全因死亡和389起心血管死亡.
- 较高的残留胆固醇 (连续) 与所有原因和心血管死亡风险的增加有关.
- 观察到非线性关联;特定四分位数显示所有原因死亡风险降低.
结论:
- 升高的残留胆固醇会增加糖尿病患者的全因和心血管死亡风险.
- 略高残留胆固醇的特定范围可能与较低的全因死亡率有关.
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