扩张性心肌病症患者的加勒-3的预后值:一个元分析
Yan Xiong1,2, Qing Zhang1
1Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
PeerJ
|April 29, 2024
概括
增加的加勒-3 (gal-3) 水平预测了扩张性心肌病 (DCM) 患者的主要不良心血管事件 (MACE). 将gal-3与晚期加多增强 (LGE) 结合起来,可以改善MACE的预测,因此需要进一步研究.
科学领域:
- 心脏病学 心脏病学
- 生物标志物 生物标志物
- 医疗成像医学成像
背景情况:
- 扩展性心肌病 (DCM) 需要准确预测心肌纤维化 (MF) 和主要不良心血管事件 (MACE).
- 加勒-3 (gal-3) 已成为DCM患者潜在的预后生物标志物.
研究的目的:
- 评估加勒-3 (加尔-3) 对DCM患者的MACEs的预后价值.
- 评估gal-3在预测MACE与晚期加多增强 (LGE) 结合的作用.
主要方法:
- 在主要数据库中进行了系统的文献搜索,直到2023年8月.
- 在DCM患者和LGE分层组中分析了gal-3和MACE的危险比率 (HR).
- 使用STATA SE 14.0软件进行了统计分析.
主要成果:
- 包括七项研究 (945名患者).
- 升高的gal-3水平与DCM中MACE风险增加有关 (HR = 1.10; p = 0.008).
- 在LGE阳性群体中,Gal-3水平高于LGE阴性群体,它们的组合改善了MACE预测.
结论:
- 升高的gal-3是DCM中MACE风险的显著相关因子.
- 作为DCM预后的生物标志物,Gal-3显示出前景,特别是在与LGE结合时.
- 由于研究异质性,需要进一步的研究来澄清gal-3的预测和诊断效用.
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