系统审查:自闭症谱系障碍和肠道微生物群
Jenni Korteniemi1, Linnea Karlsson1, Anna Aatsinki1
1FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, Psychiatry, University of Turku, Turku, Finland (Korteniemi, Karlsson, Aatsinki); Centre for Population Health Research, Turku University Hospital, University of Turku, Turku, Finland (Karlsson, Aatsinki); Department of Clinical Medicine, Paediatrics and Adolescent Medicine, Turku University Hospital, University of Turku, Turku, Finland (Karlsson).
自闭症谱系障碍 (ASD) 儿童的肠道微生物群与神经类型儿童相比显示出显著差异. 特定的细菌,如蛋白质细菌,动菌细菌和沙特雷拉,在患有自闭症的儿童中始终存在更高的水平.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 儿科 儿科 儿科
背景情况:
- 自闭症谱系障碍 (ASD) 的特点是社会互动缺陷和受限制的行为,原因不明.
- 新兴研究强调了肠-大脑轴及其与ASD症状的联系.
- 个体肠道微生物在ASD中的具体作用仍然在很大程度上是未知的.
研究的目的:
- 审查当前关于ASD和儿童肠道微生物群之间的关系的科学证据.
- 阐明ASD和肠道微生物组成之间的相互关系.
主要方法:
- 系统的文献审查.
- 专注于2-18岁的儿童.
- 检查了肠道微生物群的组成,干预措施和潜在机制.
主要成果:
- 与对照组相比,在ASD儿童中观察到肠道微生物群落的显著差异.
- 在多样性指数和分类丰度中观察到的变化.
- 一致的发现包括自闭症儿童中较高水平的蛋白质细菌,活性细菌和菌.
结论:
- 与神经型儿童相比,患有自闭症的儿童表现出改变的肠道微生物群.
- 需要进一步的研究来探索ASD肠道微生物群中的潜在生物标志物和治疗点.
- 研究结果表明,肠道微生物组变化与儿科人口中的自闭症之间存在联系.
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