美国人口有资格使用阿司匹林用于心血管疾病的初级预防
Athena L Huang1, Ann Marie Navar1, Colby Ayers1
1Division of Cardiology, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.
American journal of preventive cardiology
|April 29, 2024
概括
数百万40-59岁的美国成年人可能有资格接受阿司匹林作为动脉样硬化心血管疾病 (ASCVD) 的初级预防,根据新的指导方针. 在男性,老年人和黑人中,资格更高.
科学领域:
- 心脏病学 心脏病学
- 预防医学 预防医学
- 公共卫生 公共卫生
背景情况:
- 阿司匹林长期以来一直是动脉样硬化心血管疾病 (ASCVD) 的首要预防方法.
- 最近的试验数据引发了关于阿司匹林在ASCVD初级预防中的作用的争议.
- 美国2022年预防服务工作组 (USPSTF) 更新了在初级预防中使用阿司匹林的指导方针.
研究的目的:
- 为了确定符合初级预防资格的美国成年人患病率,阿司匹林.
- 根据2022年USPSTF指南确定符合条件的个人的人口特征.
- 为了估计更新的USPSTF建议对人口的影响.
主要方法:
- 使用国家健康和营养检查调查 (NHANES) 数据 (2011年 - 2020年3月) 进行的连续横截面研究.
- 包括40-59岁的美国成年人,没有ASCVD病史.
- 适用的10年ASCVD风险 (聚合队列方程≥10%) 和符合资格的出血风险标准.
主要成果:
- 大约有720万 (10%) 的40-59岁的美国成年人符合最初的ASCVD风险标准.
- 在排除了出血风险增加的人之后,有500万人 (年龄组的7%) 符合条件.
- 在男性,50-59岁的个人和黑人个人中,资格比例更高.
结论:
- 根据2022年USPSTF指南,符合初级预防阿司匹林的美国成年人患病率很低.
- 资格分布不均,在特定的人口群体中观察到的比例更高.
- 这些发现强调了在初级ASCVD预防策略中需要个性化风险评估.
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