PDADMAC/酸盐涂层黄金纳米机用于消灭Staphylococcus Aureus生物膜
Malarmugila Manimaran1, Yin Yin Teo2, James Chen Yong Kah3
1Department of Pharmacology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
International journal of nanomedicine
|April 29, 2024
概括
一种新的金纳米制剂有效地消灭金黄色葡萄球菌生物膜,为传统治疗提供了强有力的替代方案. 这种创新材料显示出对抗耐药细菌引起的医院感染的重大前景.
科学领域:
- 纳米技术纳米技术
- 材料科学 材料科学 材料科学
- 微生物学 微生物学
背景情况:
- 细菌生物膜导致超过75%的临床感染,特别是在医疗器械和伤口上.
- 黄金葡萄球菌 (S. aureus) 是主要的病原体,负责医院获得的感染.
- 有效地根除金黄色细菌生物膜仍然是一个重大的临床挑战.
研究的目的:
- 开发和描述一种新的聚二甲基化物 (PDADMAC) /酸盐涂层金纳米 (GNR/Alg/PDADMAC) 系统.
- 评估GNR/Alg/PDADMAC在分解预制S. aureus生物膜中的有效性.
- 评估GNR/Alg/PDADMAC与传统消毒剂的生物相容性,并比较其抗菌膜活性.
主要方法:
- 金纳米棒 (GNR) 被合成并涂上酸盐 (Alg) 和PDADMAC.
- 纳米颗粒的特征包括FTIR,泽塔潜力,TEM和UV-Vis光谱光度.
- 在S. aureus (MRSA和MSSA) 生物膜上进行了生物膜根除试验,并使用L929小鼠纤维细胞评估了生物相容性.
主要成果:
- 合成的GNR/Alg/PDADMAC纳米颗粒是生物相容的,并且有效地消除了MRSA和MSSA生物膜.
- 与triclosan相比,GNR/Alg/PDADMAC的最低生物膜消除度 (MBEC50) 显著较低.
- 在低度使用GNR/Alg/PDADMAC时,观察到生物膜迅速分解 (在17分钟内消除50%).
结论:
- GNR/Alg/PDADMAC显示出强大的抗菌膜活性对抗黄金色细菌,包括MRSA.
- 开发的纳米制剂配方是一个有希望的替代品,用于生物膜消除传统的消毒剂.
- 这项技术有可能用于临床应用,用于管理与生物膜相关的感染.
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