升高的唾液素度作为患有过敏性鼻炎的儿童喘的危险因素:一项初步研究
Haijing Sui1, Hong Shen1, Chi Zhang1
1Department of Otolaryngology, Head and Neck Surgery, Peking University First Hospital, Beijing, People's Republic of China.
升高的唾液素度 (SPC) 与儿童过敏喘有关. 较高的SPC水平与过敏性鼻炎儿童的喘控制和肺功能较差相关,这表明素是危险因素.
科学领域:
- 儿科过敏和免疫学
- 呼吸系统医学 呼吸系统医学
- 胃肠病学 胃肠病学
背景情况:
- 过敏性鼻炎在儿童中很常见,可以与喘并存.
- 胃食道逆流和素在呼吸系统疾病中的作用是正在进行的研究领域.
- 了解儿童喘的风险因素对于有效管理至关重要.
研究的目的:
- 调查唾液辛度 (SPC) 作为患有过敏性鼻炎的儿童中喘发展和控制的潜在风险因素.
- 评估SPC和喘严重程度标志物之间的关联.
主要方法:
- 一项前性研究,将20名患有过敏性鼻炎和喘的儿童与20名仅患有过敏性鼻炎的儿童进行比较.
- 测量包括分数呼出的氧化 (FeNO),肺功能测试 (FEV1/FVC,FEF75),儿童喘控制测试 (C-ACT) 分数,以及视觉模拟尺度用于鼻腔症状 (N-VAS).
- 在两组中测量了唾液素度 (SPC).
主要成果:
- 患有喘和过敏性鼻炎的儿童与仅患有过敏性鼻炎的儿童相比,SPC水平显著更高 (P < 0.001).
- 在喘组中,SPC与FeNO,FEV1/FVC,FEF50和FEF75 (P<0.05) 独立相关.
- 鼻腔症状严重程度 (N-VAS) 与FEF75,MMEF和C-ACT得分 (P <0.05) 相相关.
结论:
- 升高的唾液辛度可能是过敏性鼻炎儿童喘的重要危险因素.
- 素暴露和不受控制的鼻腔症状似乎有助于儿童过敏喘的发病和进展.
- SPC测量可以帮助识别患有或患有失控喘的风险较高的儿童.
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