在恶性固体瘤治疗中增强亚致命射频高温的治疗影响
Jiayun Liu1,2, Guilin Zhang1,2, Xinyi Li1,2
1Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Heliyon
|April 29, 2024
概括
亚致性射频高温症 (RFH) 可以通过增强化疗,放射疗,免疫疗和基因疗法来改善癌症治疗. 将RFH与这些疗法结合使用可能会减少射频切除 (RFA) 后的残留和复发瘤.
科学领域:
- 在瘤学瘤学.
- 医学物理 医学物理
背景情况:
- 射频除 (RFA) 是一种可行的手术替代方案,用于恶性固体瘤.
- 微致死性射频高温症 (RFH) 由于散热效应可能导致残留瘤,特别是较大或形状不规则的瘤,或靠近血管的瘤.
研究的目的:
- 探索亚致命RFH的潜力,以提高各种癌症治疗方式的疗效.
- 研究RFH提高化疗,放射疗法,免疫疗法和基因疗法的疗效的机制.
主要方法:
- 在癌症治疗中对RFA和RFH进行现有研究的审查.
- 对RFH介导增强其他疗法的拟议机制的分析.
主要成果:
- 已经证明,亚致死性RFH可显著提高恶性固体瘤的化疗,放射治疗,免疫治疗和基因治疗的疗效.
- 机制包括热引起的组织损伤,增加细胞膜的透性,促进新陈代谢,受损的DNA修复和热冲击蛋白激活.
结论:
- 将RFA与化疗,放射疗法,免疫疗法或基因疗法结合起来,可能利用亚致命的RFH,可能会降低残留和复发瘤的发生率.
- 这种综合方法为改善恶性固体瘤管理结果提供了一个有希望的策略.
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