与糖尿病相关的下肢伤害:抗生素敏感性模式和生物膜形成
Raha Orfali1, Safina Ghaffar1, Lateefa AlAjlan1
1Department of Pharmacognosy, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia.
概括
利雅得的糖尿病足显示出多种耐药细菌的高患病率,Serratia marcescens是最常见的病原体. 梅罗因表现出100%的对这些耐药菌株的敏感性.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 在沙特阿拉伯的利雅得,糖尿病发病率正在上升,导致糖尿病足 (DFU) 的增加.
- 糖尿病下肢伤口感染 (DLWs) 的有效治疗需要了解区域细菌患病率和抗生素耐药性模式.
- 慢性DFU中的生物膜形成有助于多药抗生素耐药性 (MDR) 和治疗失败.
研究的目的:
- 为了在利雅得医院中分离DFU的细菌.
- 评估孤立细菌的抗生素耐药性概况.
- 为了评估这些细菌的生物膜形成潜力.
主要方法:
- 从70名DFU患者中分离和识别致病微生物.
- 对各种抗生素进行抗微生物敏感性测试.
- 对生物膜形成能力的评估.
主要成果:
- 确定了63种致病微生物; 74.6%是グラム阴性.
- 大多数グラム阴性细菌对常见的抗生素表现出耐药性,但对美罗,皮佩拉西林和其他药物敏感.
- 梅罗胺对所有测试的病原体具有100%的敏感性.
- 鉴定出Serratia marcescens和Staphylococcus aureus是重要的生物膜形成者.
- 在生物膜形成的分离物中,MDR菌株占87.5%.
- 在该地区的DFU感染中,Serratia marcescens是最常见的细菌.
结论:
- 这项研究强调了MDR细菌,特别是Serratia marcescens在利雅得的DFU的重大挑战.
- 梅罗因其广泛的活性而显示出作为一种有效的治疗选择的希望.
- 结果为开发DFU基于证据的治疗策略提供了关键数据.
相关概念视频
01:29Biofilms
Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...
01:25Clinical Significance of Antibiotic Resistance
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
01:31Diabetic Foot Ulcer
Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...