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相关概念视频

Empathy02:34

Empathy

Some researchers suggest that altruism operates on empathy. Empathy is the capacity to understand another person’s perspective, to feel what he or she feels. An empathetic person makes an emotional connection with others and feels compelled to help (Batson, 1991). Empathy can be expressed in several ways, including cognitive, affective, and motor.
Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
Transducer Mechanism: G Protein–Coupled Receptors01:30

Transducer Mechanism: G Protein–Coupled Receptors

G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical, 7TM, or...
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Transducer Mechanism: Nuclear Receptors01:31

Transducer Mechanism: Nuclear Receptors

Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

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相关实验视频

Updated: Jun 23, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
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在生物医学关系提取中快速调整.

Jianping He1, Fang Li1,2, Jianfu Li1,2

  • 1McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX USA.

Journal of healthcare informatics research
|April 29, 2024
PubMed
概括

快速调整增强了生物医学关系提取 (RE) 模型,特别是在少数拍摄的学习场景中. 这种简单而有效的方法可以在没有额外资源的情况下获得最先进的结果.

关键词:
生物医学关系提取提取有几次射击学习学习.预先训练有素的语言模型快速调整调整的提示

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科学领域:

  • 生物医学信息学 生物医学信息学
  • 自然语言处理自然语言处理.

背景情况:

  • 生物医学关系提取 (RE) 对知识图和文本挖掘至关重要.
  • 适应预先训练的语言模型 (PLM) 进行RE,特别是在低数据场景中,仍然是一个挑战.

研究的目的:

  • 探索生物医学RE的快速调整,重点关注其在少数射击学习中的有效性.
  • 开发一种简单,高效和高性能的即时调模型,用于生物医学RE.

主要方法:

  • 为生物医学RE开发了一个定制的提示调模型.
  • 评估了化学蛋白关系 (CHEMPROT) 和药物相互作用 (DDI) 数据集的模型.
  • 与常规微调的PLM在少数拍摄设置中的性能进行比较.

主要成果:

  • 提示调整模型在CHEMPROT和DDI数据集上表现优于常规微调的PLM,包括少数拍摄场景.
  • 在不需要外部知识或额外的计算资源的情况下,证明了卓越的性能.
  • 通过简单而高效的方法实现了最先进的结果.

结论:

  • 快速调整是提高PLM生物医学RE能力的有效策略.
  • 拟议的模型为从生物医学文本中提取复杂关系提供了一个强大而有效的解决方案.
  • 这项工作通过为生物医学文本挖掘提供了强大的工具,从而推动了该领域的发展.