脏氧和在败血症休克儿童中的作用
Neurinda Permata Kusumastuti1,2, Teddy Ontoseno2, Anang Endaryanto2
1Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Hospital, Surabaya, East Java, Indonesia.
Journal of emergencies, trauma, and shock
|April 29, 2024
概括
近红外光谱 (NIRS) 可以预测患有败血症休克的儿童的死亡率. 通过NIRS测量的脏氧和 (rRSO2) 为儿科败血症休克结果提供了预后价值.
科学领域:
- 儿科重症监护室的儿童重症监护室
- 关键护理医学 关键护理医学
- 生物医学工程 生物医学工程
背景情况:
- 在儿童中,败血性休克带来了高死亡率和发病率.
- 败血性休克中受损的微循环与器官衰竭和死亡相关.
- 近红外光谱学 (NIRS) 提供了微循环和组织氧化的非侵入性实时评估.
研究的目的:
- 评估由NIRS测量的脏氧和 (rRSO2) 的预后意义,用于儿科败血症休克.
- 为了确定rRSO2是否可以预测患有败血症休克的儿童的死亡率.
主要方法:
- 对24名患有败血性休克的儿童 (1个月-18岁) 进行前性观察性研究.
- 用于测量基线脏氧和 (rRSO2) 的NIRS.
- 接收器运行特征 (ROC) 曲线分析以确定最佳切断,灵敏度,特异性和赔率比率 (OR).
主要成果:
- 在幸存者 (67.27 ± 12.95%) 和非幸存者 (48.69 ± 16.17%) (P = 0.006) 之间,平均基线rRSO2显著不同.
- 基线rRSO2预测死亡率的最佳切割值为<60.5%,敏感度为76.9%,特异性为81.8%.
- 在ROC曲线下的面积为0.804 (P=0.012),OR为15 (95%CI:2.04-111.74).
结论:
- 通过NIRS测量的rRSO2是儿科败血症休克死亡率的有价值预测指标.
- 较低的rRSO2水平表明,患有败血症休克的儿童死亡风险更高.
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