相关实验视频

Updated: Jun 27, 2025

Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation

Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation

Published on: November 3, 2018

红细胞分布宽度的升高是青少年骨髓单细胞白血病的独立预后因素

Weiru Liang¹, Chenmeng Liu¹, Jingliao Zhang¹

¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.

Blood science (Baltimore, Md.)

|April 29, 2024

概括

红细胞分布宽度升高 (RDW) 是青少年骨髓单细胞白血病 (JMML) 结果不佳的重要预测因素. 这种廉价的生物标志物可以帮助识别高风险患者,以便更好地进行临床管理.

科学领域:

血液学血液学血液学
儿科瘤学儿科瘤学
临床病理学临床病理学

背景情况:

青少年骨髓单细胞白血病 (JMML) 在幼儿中表现出骨髓增殖和骨髓失塑性特征.
目前对JMML的预后标记因遗传异质性而不足.
红细胞分布宽度 (RDW) 是红细胞大小变化的衡量标准,在其他疾病中具有既定的预后价值.

研究的目的:

研究RDW在被诊断为JMML的患者的预后作用.
确定RDW是否可以作为JMML结果的新,独立的预后指标.

主要方法:

从一个中心对77名JMML患者的回顾性分析 (2008年1月 - 2019年12月).
用多变量Cox比例危险模型来评估生存率.
诊断时的RDW-CV水平被分析为预测因素.

主要成果:

在诊断时RDW-CV>17.35%的患者的整体存活率明显降低 (HR = 5.22,P = .010).
较高的RDW,特别是与PTPN11突变相结合,确定了一个具有最差结果的子组.
在JMML中,RDW被确认为一个独立的预后变量.

结论:

RDW是JMML的一个有价值和独立的预后生物标志物.
RDW提供了一种廉价的工具,用于预测患有JMML的儿科患者的临床结果.
纳入RDW评估可能会改善JMML的风险分层和管理策略.

关键词:

独立的预后因素是一个独立的预后因素.青少年骨髓单细胞白血病 (JMML) 是一种红细胞分布宽度红细胞分布宽度

更多相关视频

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

Flow Cytometric Analysis of Mitochondrial Reactive Oxygen Species in Murine Hematopoietic Stem and Progenitor Cells and MLL-AF9 Driven Leukemia

Flow Cytometric Analysis of Mitochondrial Reactive Oxygen Species in Murine Hematopoietic Stem and Progenitor Cells and MLL-AF9 Driven Leukemia

Published on: September 5, 2019

相关概念视频

Differentiation of Common Myeloid Progenitor Cells

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...

Disorders of Leukocytes

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...