益生菌:塑造肠道免疫反应
Eirini Filidou1, Leonidas Kandilogiannakis1, Anne Shrewsbury2
1Faculty of Medicine, Laboratory of Pharmacology, Democritus University of Thrace, Alexandroupolis 68100, Greece.
World journal of gastroenterology
|April 29, 2024
概括
益生菌,有益的活微生物,改善肠道健康和免疫反应. 最近的研究强调了它们在控制肠道炎症和支持肠道微生物群方面的作用,为炎症性肠道疾病 (IBD) 提供治疗潜力.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 益生菌是提供健康益处的活微生物.
- 乳酸菌群,双菌群和酵母菌群是经过充分研究的益生菌.
- 在IBD中常见的肠道炎症涉及微生物群失衡和粘膜损伤.
研究的目的:
- 审查最近关于益生菌对肠道免疫的影响的体外和体内研究.
- 为了确定有益的益生菌物种对肠道炎症.
- 分析影响肠道环境的益生菌机制.
主要方法:
- 过去两年的体外和体内研究的综述.
- 对益生菌对肠道微生物群组成的影响的分析.
- 评估益生菌对宿主免疫反应和组织微环境的影响.
主要成果:
- 益生菌可以改善肠道微生物群的组成,促进伤口愈合.
- 它们调节免疫反应并保护宿主.
- 益生菌可以取代病原体并提供必需的营养素.
结论:
- 益生菌及其代谢物 (后生菌) 对肠道健康和免疫有积极的影响.
- 尽管IBD的临床结果有争议,但它们的有益作用是显而易见的.
- 特定的益生菌属在对抗肠道炎症方面表现有前途.
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