在非酒精性脂肪肝疾病中,肉症的患病率和结局
Suprabhat Giri1, Prajna Anirvan2, Sumaswi Angadi3
1Department of Gastroenterology and Hepatology, Kalinga Institute of Medical Sciences, Bhubaneswar 751024, Odisha, India.
World journal of gastrointestinal pathophysiology
|April 29, 2024
概括
麻症 (肌肉质量下降) 在非酒精性脂肪性肝病 (NAFLD) 中很常见,并与晚期肝纤维化,心血管风险和死亡率有关. 为了改善患者的治疗结果,需要标准化的诊断标准.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 老年病的医生 老年病的医生
- 代谢疾病 代谢疾病
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 涵盖了一系列肝脏疾病,从肥胖症到纤维化.
- 由肌肉力量和质量减少而定义的肉类,与NAFLD具有病理生理联系.
- 现有的关于麻症患病率和NAFLD患者的结果的数据不一致.
研究的目的:
- 系统地分析被诊断为NAFLD的患者中肉类的患病率.
- 调查萨科佩尼亚对NAFLD患者临床结果的影响.
主要方法:
- 在MEDLINE,Embase和Scopus进行了全面的文献搜索,截至2023年6月.
- 包括专注于NAFLD患者的研究,报告了sarcopenia的患病率,并检查了肝纤维化和不良事件等二次结果.
- 研究质量使用纽卡斯尔-太华尺度进行评估.
主要成果:
- 在NAFLD患者中,肉类的患病率差异很大 (1.6%63.0%),大多数研究报告超过10.0%.
- 在各种评估方法中,sarcopenia与晚期肝纤维化风险增加有关 (OR: 1.97;95% CI: 1.442.70).
- 在NAFLD中 Sarcopenia 与脂肪肝炎,胰岛素耐药性,心血管问题和死亡率的风险更高相关.
结论:
- 对于NAFLD中肉类症的标准化诊断标准和测量方法有极大需求.
- 研究设计和评估工具的变化可能解释了关于肉病和肝纤维化不一致的发现.
- 肉类症在肝脏特异性并发症之外显著影响NAFLD,影响心血管健康,死亡率和代谢状态.
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