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尼帕病毒在空间尺度上的遗传多样性

Oscar Cortes-Azuero¹, Noémie Lefrancq¹, Birgit Nikolay²

¹Department of Genetics, University of Cambridge, Cambridge, United Kingdom.

The Journal of infectious diseases

|April 29, 2024

概括

蝙蝠中的尼帕病毒 (NiV) 多样性被低估,即使在里,多个遗传集群也在共同循环. 了解这种复杂的NiV景观对于防止未来爆发至关重要.

科学领域:

病毒学病毒学
基因组学就是基因组学.
流行病学流行病学

背景情况:

尼帕病毒 (NiV) 是一种高度致命的动物性病毒,在南亚和东南亚的类蝙蝠中传播.
对蝙蝠中NiV遗传多样性的有限理解,阻碍了有效的疾病控制和疫情预测.

研究的目的:

在蝙蝠种群中全面分析尼帕病毒遗传多样性.
估计NiV遗传集群的空间分布和共同循环模式.

主要方法:

从6个国家收集了257个NiV基因组 (175个来自蝙蝠,73个来自人类) 在22年 (1999-2020年) 时间内进行的家族遗传学分析.
主要NiV亚系的划分为15个遗传集群.
应用近似贝叶斯计算来建模空间病毒多样性并估计集群流行率和规模.

主要成果:

蝙蝠中平均有2.4 NiV的基因群共同循环,在更大的区域 (1500-2000平方公里) 增加到5.5个群.
每个NiV遗传集群占据估计平均面积为130万平方公里.
在集中地点 (孟加拉国,柬埔寨) 的基因组监测已经确定了大多数集群,但只发现了约15%的总NiV多样性.

结论:

不同的尼帕病毒血统根深蒂固,并共同循环,甚至在单个蝙蝠里.
在更大的空间尺度上,NiV表现出缓慢的迁移模式.
目前的基因组监测可能低估了NiV多样性的全部程度,需要更广泛的采样策略.

关键词:

这种动物叫Pteropus.尼帕病毒是尼帕病毒.疾病建模疾病建模新兴的病原体新兴的病原体人类遗传学遗传学

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