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肺纤维化中的细胞的研究进展

Xiaobo He¹, Yuanhang Fan¹, Yihuan Lai¹

¹Department of Critical Care Medicine; Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; The Third Affiliated Hospital of Guangzhou Medical University, 510150 Guangzhou, Guangdong, China.

Frontiers in bioscience (Landmark edition)

|April 29, 2024

概括

细胞通过引起肺炎和激活纤维细胞来驱动肺纤维化 (PF). 准这些细胞为PF提供了潜在的新疗法.

科学领域:

肺部医学肺部医学
细胞生物学细胞生物学
病理学病理学病理学

背景情况:

细胞是介质细胞,是肺血管系统的组成部分.
它们是严重肺病,特别是肺纤维化 (PF) 的关键病理参与者.
细胞的存在与肺炎和间歇性/气膜纤维化有关.

研究的目的:

综合回顾肺纤维化中皮质细胞的作用.
阐明皮质细胞对肺炎和纤维化有所贡献的机制.
探索用于肺纤维化治疗的细胞向疗法.

主要方法:

审查现有的文献在PF中围细胞功能.
分析涉及 pericyte 作用的信号通路 (例如,TGF-β,Wnt).
检查介细胞介导的纤维细胞激活和细胞外矩阵重塑.

主要成果:

细胞释放细胞因子和化学因子,促进炎症和纤维化.
细胞刺激纤维细胞的增殖和激活,加剧PF.
TGF-β和Wnt信号通路是围细胞驱动的PF进展的关键调解者.

结论:

细胞是肺纤维化病原体的重要驱动因素.
了解细胞周围细胞机制对于PF研究至关重要.
针对危险细胞的策略代表了PF的有希望的治疗途径.

关键词:

肌纤维母细胞细胞.周围细胞 (pericytes) 是一个细胞.肺部纤维化肺部纤维化转化转化转化转化转化转化转化转化

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