改变休息状态桃体功能连接在初级角度闭眼患者
Ye Chen1, Yuanyuan Wang1, Linglong Chen1
1Department of Radiology, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi, China.
Journal of integrative neuroscience
|April 29, 2024
概括
主要闭角光眼 (PACG) 患者表现出大脑连接的改变,特别是在杏仁体. 功能连接 (FC) 的这些变化可能会导致这种情况.
科学领域:
- 神经科学是一个神经科学.
- 眼科医生 眼科 眼科
- 放射学 放射学是一门学科.
背景情况:
- 玻璃眼与抑郁症状有关,与杏仁体活动有关.
- 玻璃眼中的杏仁核功能连接 (FC) 变化没有得到充分的记录.
- 主要闭角光眼 (PACG) 作为研究这些变化的模型.
研究的目的:
- 为了评估桃体功能连接 (FC) 在初级角度闭合光眼 (PACG) 患者的变化.
- 为了比较PACG患者和健康对照者 (HCs) 之间的桃体静止状态FC.
- 探索改变的杏仁体FC与PACG中的临床变量之间的关系.
主要方法:
- 使用了休息状态功能磁共振成像 (rs-fMRI).
- 招募了36名PACG患者和33名HC患者.
- 双边桃体被用作FC分析的种子区域.
主要成果:
- 与HC相比,PACG患者的桃体FC与小脑,虫,额头和运动区域以及骨显得减少.
- 在PACG患者的左桃体和右桃体之间观察到增强的FC.
- 改变的FC与临床参数或疾病持续时间之间没有发现显著的相关性.
结论:
- PACG患者表现出广泛的休息状态功能连接异常,涉及桃体.
- 失调的杏仁体FC与PACG的病理生理学有关.
- 这些发现突显了PACG超越眼部变化的神经生物学基础.
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