烯改变了脑血速和血压之间的相同步在ME/CFS与静态不耐受性
Marvin S Medow1,2, Julian M Stewart1,2
1Department of Pediatrics, New York Medical College, Valhalla, New York, United States.
概括
在患有肌痛性脑膜炎/慢性疲劳综合征 (ME/CFS) 和静止不耐受症的患者中,烯改善了认知功能和大脑自身调节. 这种干预有效地抵消了垂直的低头,并维持了大脑血液的速度,与CO2或乙胺不同.
科学领域:
- 神经科学是一个神经科学.
- 心血管生理学心血管生理学
- 医学研究 医学研究
背景情况:
- 肌痛性脑筋炎/慢性疲劳综合征 (ME/CFS) 与静止不耐受性 (OI) 与神经认知缺陷有关,可能是由于直立低头症和大脑自调节 (CA) 障碍.
- 患有ME/CFS的患者经常表现出姿势性心跳动综合征 (POTS),其特点是头部向上倾斜 (HUT) 期间出现显著的生理变化,包括心脏和呼吸率的增加和潮末CO2 (ETCO2) 的降低.
- 与对照组相比,ME/CFS患者的直立姿势导致脑血流速度 (CBV) 降低,这表明脑血流调节受损.
研究的目的:
- 调查干预措施 (CO2,,乙胺) 对ME/CFS患者在静止性压力期间神经认知功能和大脑自身调节的影响.
- 为了确定基是否可以减轻脑血流速度的正静性减少,并改善ME/CFS和POTS患者的认知表现.
- 评估这些干预措施对相同步指数 (PhSI) 作为大脑自我调节的衡量标准的影响.
主要方法:
- 在15名ME/CFS患者 (有POTS) 和11名对照者中,进行了N-back神经认知测试和动脉压 (AP) 和脑血速 (CBV) 之间的相同步指数 (PhSI) 计算.
- 测量是在躺着和在10分钟的60°抬头倾斜 (HUT) 之前和之后服用额外的CO2,烯 (PE) 或乙胺.
- 分析了心率,呼吸率,ETCO2,CBV和N-back性能 (%正确) 的变化,以评估每个干预措施的有效性.
主要成果:
- 与对照组相比,抬头倾斜显著增加了ME/CFS患者的生理压力,其特征是心脏和呼吸率更高,ETCO2更低,CBV降低.
- 只有烯的使用在ME/CFS患者中改善了直立N-back的性能,使其恢复到与对照组相比的水平,并显著降低了PhSI,表明大脑自调节得到改善.
- 在ME/CFS患者的HUT期间,CO2和酸并没有改善神经认知功能或大脑自身调节 (PhSI),尽管烯的积极作用.
结论:
- 烯有效地改善了ME/CFS患者在静止挑战期间的神经认知功能,可能是通过增强神经血管合,改善大脑自身调节和维持大脑血液速度.
- 这些发现表明,烯的好处源于其抵消高通风,增加二氧化碳水平,并直接改善大脑自调节的能力,与二氧化碳或乙醇胺不同.
- 这项研究强调了烯作为一种潜在的治疗剂,用于管理与ME/CFS中静态不耐受性相关的认知缺陷.
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