在高剂量双疗法和高剂量双疗法治疗Helicobacter pylori根除后,肠道微生物群的动态变化
Jing Chen1,2, Yan Zhang2, Hanchen Min1,2
1Medical School of Chinese PLA, Beijing, China.
Helicobacter
|April 29, 2024
概括
高剂量双疗法 (HDDT) 针对H. pylori根除,与木四重疗法 (BQT) 相比,对肠道微生物群的影响较轻. 与BQT不同,肠道微生物多样性在HDDT中反弹,这表明治疗后恢复更好.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 医学科学 医学科学 医学科学
背景情况:
- 高剂量双疗法 (HDDT) 是一种新的H. pylori根除疗法.
- 对于HDDT对肠道微生物群的影响尚不完全理解.
- 这项研究比较了HDDT对肠道微生物群的影响与木四重疗法 (BQT).
研究的目的:
- 评估HDDT对肠道微生物群组成和多样性的影响.
- 为了比较HDDT和BQT对肠道微生物群的影响.
- 评估H. pylori根除治疗后肠道微生物群的恢复情况.
主要方法:
- 患有H. pylori感染的门诊患者被随机分配到HDDT或BQT.
- 在基线,第2周和第14周收集了便样本.
- 使用16S rRNA基因测序来分析肠道微生物群的组成.
主要成果:
- 无论是HDDT还是BQT都改变了肠道微生物群的多样性.
- 阿尔法多样性在12周的消除后,在HDDT组中反弹.
- 在根除后,蛋白质细菌占主导地位,Firmicutes和Bacteroidetes的恢复有限.
- 在两组中,Klebsiella pneumoniae和Escherichia fergusonii等特定物种的增加.
- 在BQT组中菌种类增加,但在HDDT组没有显著增加.
- 在12周后,在HDDT组中,更多物种恢复到基线水平.
结论:
- 根除H. pylori可以破坏肠道微生物群平衡.
- 与BQT相比,HDDT对肠道微生物群的影响较轻.
- HDDT可能会促进更好的肠道微生物在根除后的恢复.
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