在炎症条件下,结肠中可用的果 (多) 在人类肠道细胞单层中对肠道屏障功能表现出缓解作用
Gema Pereira-Caro1,2, Salud Cáceres-Jiménez3, Alicia Moreno-Ortega1,2
1Department of Agroindustry and Food Quality, Andalusian Institute of Agricultural and Fisheries Research and Training (IFAPA), Alameda del Obispo, Córdoba, Spain. mariag.pereira@juntadeandalucia.es.
Food & function
|April 29, 2024
概括
果液中的多可以保护肠道屏障功能免受炎症压力. 这些化合物,包括酸,减轻损伤和减少炎症标志物,突出显示了对肠道健康的潜在饮食益处.
科学领域:
- 胃肠病学 胃肠病学
- 营养科学 营养科学
- 细胞生物学 细胞生物学
背景情况:
- 肠道屏障功能障碍与炎症状况有关.
- 饮食中的多因其抗氧化和抗炎性质而闻名.
- 果的消费将生物活性多提供给结肠.
研究的目的:
- 为了研究大肠中可用的果多对压力诱导的肠道屏障损伤的影响.
- 为了分析果后消费的叶液的多烯成分.
- 在炎症条件下评估叶液提取物对肠道细胞的保护作用.
主要方法:
- 果-2/HT29-MTX细胞被处理成果前后消费的叶液提取物.
- 炎症性压力被诱导使用cytomix.
- 表皮屏障功能通过跨表皮电阻 (TEER) 进行评估.
- 量化了炎症标志物 (IL-8,NO) 和MUC2的产生.
- 使用UHPLC-HR-MS.进行了多醇分析.
主要成果:
- 果摄入后的体液含有酸,氧和基衍生物.
- 个别的叶液提取物显示出不同的保护作用.
- 果衍生的阴道液提取物在炎症性压力下显著降低了TEER的减少.
- 提取物减轻了炎症挑战诱导的酸盐分泌 (NO代理) 和MUC2降低.
- 保护作用与IL-8或克劳丁-7的变化无关.
结论:
- 在结肠中可获得的果多可以保护肠道屏障免受炎症损伤.
- 叶液中的特定多代谢物在缓解屏障功能障碍方面发挥着作用.
- 果多是一种潜在的饮食策略,可以在炎症期间支持肠道健康.
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