候选病的流行病学模式:在十年的时间里进行了全面的分析
Gordon Ferngren1, David Yu1, Tugce Unalan-Altintop1,2
1Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Mycoses
|April 29, 2024
概括
多微生物真菌血流感染 (BSI) 是常见的,通常涉及混合的Candida和细菌物种. 虽然Candida albicans仍然普遍存在,但Nakaseomyces glabrata和Candida parapsilosis显示出候选病例的增加趋势.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 在全球范围内,真菌血流感染 (BSI),特别是候选血症,正在上升.
- 由于生长缓慢和专业专业知识的要求,真菌感染的准确和及时诊断受到阻碍.
- 多微生物真菌感染使诊断和治疗策略复杂化,需要强大的流行病学数据.
研究的目的:
- 为了界定单微生物候群病的流行病学.
- 描述多微生物BSI的流行病学,包括混合菌病和混合Candida/细菌BSI.
主要方法:
- 进行了一项单一中心的回顾性流行病学研究.
- 分析了2010年至2020年期间收集的950,161种血液培养的数据.
- 电子健康记录被用于调查单微生物和多微生物候群病发作.
主要成果:
- 从2010年到2020年,在1144名患者中确定了1334次候选血病发作.
- 最常见的物种是Candida albicans (57.7%),但呈现下降趋势.
- 纳卡西奥米切斯格拉布拉塔和坎迪达帕拉西洛斯复合体的发病率呈上升趋势.
- 多微生物BSI发生在19.8%的发作中,混合Candida/细菌BSI发生在17%和混合菌病发生在2.8%中.
结论:
- kandidatemia 中的多微生物生长很常见,主要是作为混合的 Candida/细菌 BSIs.
- 虽然Candida albicans是最常见的,但它正在减少,而C. parapsilosis复合体和N. glabrata正在增加.
- 流行病学见解对于开发有效的实证治疗策略来对抗升的真菌BSI至关重要.
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