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Updated: Jun 27, 2025

In vitro Organoid Culture of Primary Mouse Colon Tumors
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YY2/BUB3轴通过调节染色体不稳定性促进SAC过活化并抑制结肠直肠癌的进展

Rendy Hosea1,2, Wei Duan1,2, Ian Timothy Sembiring Meliala1,2

  • 1Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400045, P. R. China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|April 29, 2024
PubMed
概括

螺旋组合检查点 (SAC) 调节了线粒分裂. 这项研究确定YY2是影响SAC活动的线粒调节剂,影响瘤生长,细胞死亡和药物敏感性,提供新的治疗策略.

关键词:
染色体的不稳定性 (CIN)药物耐药性 耐药性 药物耐药性发生线粒分裂 (mitosis).剩余的瘤细胞.阴阳2 (YY2) 的阴阳2 (YY2)

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Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter11:32

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