从临床样本中分子确认的Aspergillus物种的抗真菌敏感性
M N Tzar1, S Mustakim2, H Yusoff3
1Universiti Kebangsaan Malaysia, Faculty of Medicine, Department of Medical Microbiology and Immunology, Kuala Lumpur, Malaysia. tzar@ppukm.ukm.edu.my.
The Malaysian journal of pathology
|April 29, 2024
概括
抗真菌敏感性测试显示,Aspergillus niger和Aspergillus fumigatus在很大程度上对常见的抗真菌药物 (如安福特素B和阿醇) 很容易受到影响,这指导了经验性阿斯伯吉洛症治疗.
科学领域:
- 医学真菌学 医学真菌学
- 抗生素敏感性测试 抗生素敏感性测试
背景情况:
- 侵袭性阿斯伯吉洛症是一种显著的人类真菌病,具有有限的特定物种抗真菌易感性数据.
- 对阿斯伯吉洛症的实证抗真菌治疗往往缺乏精确的易感性指导.
研究的目的:
- 为了确定从临床标本中分离出的阿斯伯吉勒斯菌种的抗真菌敏感性概况.
- 为了告知侵入性阿斯伯吉洛症的实证抗真菌疗法.
主要方法:
- 使用内部转录间隔器 (ITS) 和β-tubulin基因测序识别了28种Aspergillus分离物.
- 使用Sensititre YeastOne进行的抗真菌敏感性测试,结果与EUCAST断点进行解释.
主要成果:
- 黑色阿斯珀吉洛斯 (60.7%) 是最常见的分离物,其中94.1%对安福特素B敏感.
- 所有的Aspergillus fumigatus分离物 (100%) 都对安福特素B,伊特拉可纳和沃里可纳敏感.
- 观察到阿斯伯吉illus flavus对伊特拉科纳的高度敏感率.
结论:
- 在临床环境中,Aspergillus niger仍然是占主导地位的物种.
- 阿斯珀吉卢斯分离体对安福特素B,类素和大多数醇具有广泛的敏感性.
- 这些发现支持目前对阿斯伯吉洛症的抗真菌治疗策略.
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