老年人中故意发生的二胺中毒报告给美国中毒中心
Namkee G Choi1, Bryan Y Choi2, C Nathan Marti1
1Steve Hicks School of Social Work, The University of TX at Austin, Austin, TX, USA.
Clinical toxicology (Philadelphia, Pa.)
|April 29, 2024
概括
老年人对二二的滥用正在下降,但更危险,严重后果和死亡风险增加. 医疗保健提供者应该选自杀念头,并管理多药,以减少伤害.
科学领域:
- 药物监督 药物监督 药物监督
- 老年医学 老年医学
- 毒理学 毒理学 毒理学
背景情况:
- 对于老年人来说,尽管有 kontraindications,但Benzodiazepines经常被处方给老年人.
- 这种人群容易受到药物不良事件和故意滥用的影响.
研究的目的:
- 为了比较与 bensodiazepine 相关的自杀企图与 50 岁及以上成年人其他故意滥用病例的特征.
- 在这些情况下,检查与严重的医疗结果 (重大影响/死亡) 相关的因素.
主要方法:
- 利用美国毒药中心国家毒药数据系统 (2015-2022) 的数据.
- 采用描述性统计和二进制物流回归模型.
主要成果:
- 涉及二二胺的故意滥用病例 (n=93,245) 占85%的自杀未遂和15%的其他故意滥用.
- 虽然总体报告下降,自杀企图和严重后果的可能性增加了2019-2022年与2015-2016年相比.
- 同时服用抗抑郁药,阿片类药物,抗精神病药,抗药和酒精与增加自杀企图的可能性和严重后果有关.
结论:
- 尽管老年人对二二类药物滥用报告的数量有所下降,但结果的严重程度有所增加.
- 医疗保健提供者必须对自杀念头进行查,特别是在服用抗抑郁药和阿片类药物的同时使用者中.
- 对心理健康,物质使用和药物治疗方案的全面评估至关重要,以尽量减少多药和减少不良事件.
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