药物加载的粘合性微粒用于预防口腔表面上的生物膜
Min Jun Oh1,2, Jae-Hyun Kim1, Jaekyoung Kim1
1Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. daeyeon@seas.upenn.edu.
Journal of materials chemistry. B
|April 29, 2024
概括
新的树突型微粒强烈粘附于口腔表面,有效地提供抗真菌治疗,以对抗具有挑战性的Candida albicans生物膜. 这项创新为口腔感染提供了一个有前途的解决方案.
科学领域:
- 生物材料科学 生物材料科学
- 口腔微生物学 口腔微生物学
- 药物输送系统 药物输送系统
背景情况:
- 口腔中含有像Candida albicans这样的微生物,形成有弹性的生物膜,导致难以治疗的感染.
- 生物膜对传统疗法的耐药性以及在动态的口腔环境中药物输送的挑战需要新的方法.
- 由于口腔复杂性,当前的治疗方法与抗菌素耐药性和有效的药物输送扎.
研究的目的:
- 开发和评估新的树突性微粒,以增强对口腔表面的附着性.
- 评估这些微粒在提供抗真菌剂和抗菌膜酶方面的有效性.
- 研究这些微粒在对抗口腔中的Candida albicans生物膜方面的潜力.
主要方法:
- 使用与PLGA共聚合物的水-油-水乳液技术制造树突型微粒.
- 评估微粒对各种口腔表面的粘附,包括牙树脂,酸,牙和粘膜组织.
- 评估尼斯塔丁释放动力学,生物降解和抗生物膜有效性对抗白菌.
主要成果:
- 与球形颗粒相比,状微粒对口腔表面的附着性更强.
- 观察到nystatin从微粒中持续释放,显示其在杀死Candida albicans方面的有效性.
- 微粒在牙表面呈现生物降解,并有效防止真菌生物膜的形成.
结论:
- 工程 dendritic 微粒提供增强的附着性,用于在口腔中向药物输送.
- 这些粘合性微粒是治疗口腔生物膜相关感染的有希望的策略.
- 开发的系统有效地提供抗真菌剂,并防止微生物生物膜的增殖.
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