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Updated: Jun 27, 2025

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
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衰老的CAFs可以调节免疫抑制并驱动乳腺癌的进展

Jiayu Ye1, John M Baer2, Douglas V Faget1

  • 1Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri.

Cancer discovery
|April 29, 2024
PubMed
概括

衰老癌症相关纤维细胞 (senCAFs) 通过抑制自然杀手 (NK) 细胞活性来促进乳腺癌的生长. 消除senCAF释放NK细胞,限制瘤的进展,并提供一个潜在的老化疗法目标.

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