抗高血糖药物对COVID-19的影响:从观察性研究中进行的元分析和系统审查
Zhi-Hui Song1, Qiao-Ming Huang1, Shan-Shan Xu1
1Department of Pharmacy, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Therapeutic innovation & regulatory science
|April 29, 2024
概括
甲胺,GLP-1受体激动剂和SGLT2抑制剂可能会降低COVID-19糖尿病患者的死亡率和严重程度. 然而,胰岛素使用与风险增加有关,特别是在老年人中,因此需要谨慎使用.
科学领域:
- 内分泌学 在内分泌学.
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 糖尿病是一种全球性的慢性疾病.
- 患有COVID-19的糖尿病患者可能面临更差的预后.
- 某些抗高血糖药物可能会影响COVID-19的结果.
研究的目的:
- 分析抗高血糖药物对COVID-19临床结果的影响.
- 确定与改善或恶化预后相关的特定药物类别.
主要方法:
- 在主要数据库 (PubMed,Scopus等) 进行系统的文献搜索. 从2019年12月开始到2022年6月.
- 包括56项检查COVID-19患者2型糖尿病 (T2DM) 治疗抗高血糖药物的研究.
- 对治疗对死亡率,严重程度和住院风险的影响的元分析.
主要成果:
- 甲胺,GLP-1受体激动剂 (GLP-1ra) 和SGLT2抑制剂与显著降低的死亡风险相关 (ORs < 1, p < 0.05).
- 这些药物 (甲胺,GLP-1ra,SGLT2i) 也显示严重的COVID-19表现和住院住院的风险降低.
- 胰岛素使用与增加的死亡率 (OR 1.40) 和住院 (OR 1.31) 风险有关,特别是在老年患者中.
结论:
- 甲胺,GLP-1ra和SGLT2抑制剂对COVID-19的结果产生有益影响,特别是在非老年人中.
- 胰岛素治疗可能会增加COVID-19患者,特别是老年人的风险,需要仔细考虑.
- DPP-4 抑制剂,TZD,α-GLU 和硫尿素显示出中性作用;需要进一步的临床验证.
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