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在新时代的迷幻辅助治疗中:随机对照试验中研究方法的系统审查

Paul S Soliman^1,2, Dallece E Curley^1,3, Christy Capone^1,4,5

¹Center for Alcohol and Addiction Studies, Brown University, Providence, RI, USA.

Psychopharmacology

|April 29, 2024

概括

在迷幻研究中的盲目是具有挑战性的. 传统的安慰剂不足以控制精神疾病随机对照试验 (RCT) 的预期寿命. 未来的研究需要改进遮方法.

科学领域:

精神病学是一个精神病学.
心理药理学心理药理学
临床试验临床试验

背景情况:

随机化,安慰剂对照试验 (RCT) 使用迷幻药与辅助治疗 (AT) 在精神疾病方面正在增加.
在迷幻AT中有效的蒙蔽是一个重大的方法挑战.
不充分的盲目可能导致响应偏差,内部有效性降低,参与者保留受损.

研究的目的:

系统地审查精神疾病的迷幻RCT中的盲目化技术.
确定可以为未来的RCT设计在迷幻研究中提供信息的因素.
为了解决心理迷幻辅助疗法中盲目的方法学挑战.

主要方法:

对多个数据库 (PubMed,MEDLINE,CINAHL,CENTRAL,Psycinfo,Embase,Web of Science) 的系统审查. 这些数据库包括:
检查安慰剂选择,研究设计和在确定出版物中的盲目完整性.
纳入标准侧重于使用迷幻药和安慰剂治疗精神疾病的RCT.

主要成果:

十六个出版物符合系统审查的标准.
传统的安慰剂管理不足以控制心理研究中的预期混.
限制人员解盲和使用活性安慰剂的实验设计至关重要.

结论:

目前在迷幻实验中使用的盲目的方法往往是不够的.
未来的迷幻药物研究需要创新的方法方法来确保强大的失明.
考虑活性安慰剂和减少人员暴露是有效研究设计的关键.

关键词:

辅助治疗是一种辅助疗法.这是MDMA,MDMA.避孕药是一种安慰剂.心理药物心理药物

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